Pharmacological and Clinical Aspects of Heme Oxygenase

@article{Abraham2008PharmacologicalAC,
  title={Pharmacological and Clinical Aspects of Heme Oxygenase},
  author={N. Abraham and A. Kappas},
  journal={Pharmacological Reviews},
  year={2008},
  volume={60},
  pages={127 - 79}
}
This review is intended to stimulate interest in the effect of increased expression of heme oxygenase-1 (HO-1) protein and increased levels of HO activity on normal and pathological states. The HO system includes the heme catabolic pathway, comprising HO and biliverdin reductase, and the products of heme degradation, carbon monoxide (CO), iron, and biliverdin/bilirubin. The role of the HO system in diabetes, inflammation, heart disease, hypertension, neurological disorders, transplantation… Expand
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