Pharmacological analysis of the haemodynamic effects of 5-HT1B/D receptor agonists in the normotensive rat.

@article{Pagniez1998PharmacologicalAO,
  title={Pharmacological analysis of the haemodynamic effects of 5-HT1B/D receptor agonists in the normotensive rat.},
  author={F Pagniez and J. P. Valentin and Sylvie Vieu and F. C. Colpaert and Gareth W. John},
  journal={British journal of pharmacology},
  year={1998},
  volume={123 2},
  pages={205-14}
}
1 The receptors involved in mediating the haemodynamic effects of three 5-HT1B/D receptor agonists were investigated in pentobarbitone anaesthetized rats (n = 6-17 per group). 2 Cumulative intravenous (i.v.) infusions of rizatriptan and sumatriptan (from 0.63 to 2500 microg kg(-1); each dose over 5 min) induced dose-dependent and marked hypotension (-42+/-6… CONTINUE READING