Pharmacological analysis of beta adrenoceptor blockade-induced coronary blood flow redistribution in dogs using l-penbutolol.

The effects of l- and d-penbutolol on regional myocardial blood flow (assessed by means of tracer microspheres) and on ST-segment elevation in ischemic and nonischemic areas of the canine left ventricle have been investigated under different experimental conditions. l-Penbutolol reduced transmural coronary blood flow and induced its redistribution from the… CONTINUE READING