Pharmacological agents for the control of spontaneous ventricular fibrillation under progressive hypothermia.

@article{Angelakos1959PharmacologicalAF,
  title={Pharmacological agents for the control of spontaneous ventricular fibrillation under progressive hypothermia.},
  author={Evangelos Theodorou Angelakos and Albert H. Hegnauer},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1959},
  volume={127},
  pages={
          137-45
        }
}
Quinidine, procaine amide, seven new antiarrhythmics, eleven antihistaminics, four local anesthetics, six antimalarials, and a few other compounds were tested for their ability to protect the canine heart from spontaneously occurring ventricular fibrillation (VF) during progressive immersion hypothermia. Several of these compounds were eliminated as "noneffective" with a high degree of statistical confidence on the basis of screening tests. Extensive tests at various doses were performed with… 
THE EFFECT OF THE AMINOSTEROID, ORG 6001, ON HYPOTHERMIA‐INDUCED VENTRICULAR FIBRILLATION IN THE CAT
TLDR
A protective effect of the antidysrhythmic aminosteroid, ORG 6001, on hypothermia‐induced ventricular fibrillation was investigated in cats anaesthetized with pentobarbitone and the number of animals that survived to 16°C was increased.
INFLUENCE OF PHARMACOLOGICAL AGENTS ON SPONTANEOUS AND SURGICALLY INDUCED HYPOTHERMIC VENTRICULAR FIBRILLATION *
  • E. Angelakos
  • Biology
    Annals of the New York Academy of Sciences
  • 1959
TLDR
A review of studies carried out in the laboratory with a variety of compounds over the last three years in attempts to delineate active agents, finding that study of the changes in the electrophysiological properties brought about by effective compounds may provide valuable clues as to the fundamental mechanisms that play a dominant role.
Conversion of atrial fibrillation with antazoline hydrochloride (Arithmin).
TLDR
This paper was read on December 7, 1968, by Dr. T. Shepard of Pittsburgh, Penna., for Dr. Gehring due to the hospitalization of Dr. Geoffrey Gehring.
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