Corpus ID: 212458633

Pharmacological activities palmatine alkaloid compound isolated from Guatteria friesiana prospects for new drug development

  title={Pharmacological activities palmatine alkaloid compound isolated from Guatteria friesiana prospects for new drug development},
  author={Soane Kaline Morais Chaves and Chistiane Mendes Feitosa and Felipe Pereira da Silva Santos and Joilane Alves Pereira Freire},
  journal={Asian Journal of Biomedical and Pharmaceutical Sciences},
Medicinal plants have been used for thousands of years for the treatment of numerous diseases becoming an important source in the search for new drugs. Among the substances, palmatine, arising from natural sources, an alkaloid has been investigated with regard to their pharmacological actions and has demonstrated promising activity for the treatment of various diseases highlighting Alzheimer's disease (AD). The aim of this study was to verify the state of the art and technique on palmatine with… Expand
3 Citations
Palmatine: A review of pharmacological properties and pharmacokinetics
The aim of this review is to collect together the results of the numerous studies over the last two decades on the pharmacological properties of palmatine published in scientific databases likeExpand
Integrating in vitro and in silico approaches to evaluate the "dual functionality" of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils.
BACKGROUND Alzheimer's disease (AD) is the most common neurodegenerative disorder which is characterized by the deposits of intra-cellular tau protein and extra-cellular amyloid-β (Aβ) peptides inExpand
The Effect of Harmaline on Aspartate Aminotransferase, Alanine Aminotransferase, and Albumin in Normal and Diabetic Rats
It was shown that taking harmaline caused a disturbance in the balance of liver enzymes and elevated serum albumin levels in healthy and diabetic rats, while liver enzymes increased in diabetic groups as dosage increased. Expand


Synergistic Inhibition on Acetylcholinesterase by the Combination of Berberine and Palmatine Originally Isolated from Chinese Medicinal Herbs
Berberine and palmatine, two isoquinoline alkaloids found in several medicinal herbs, were used for memory enhancement in China and might potentially be developed as a more effective therapeutic strategy for Alzheimer’s disease patients. Expand
In vitro and in vivo antitumor effects of the essential oil from the leaves of Guatteria friesiana.
It is concluded that EOGF possesses significant antitumor activity and has only low systemic toxicity. Expand
A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species.
Three berberine, berbamine and palmatine alkaloids were shown to possess dose-dependent antinociceptive activity, which assessed by using the model based on the inhibition of p-benzoquinone-induced writhing movements as well as antipyretic activity on FCA-induced increased rectal temperature on subacute administration. Expand
Seasonal Variation of Alkaloid Contents and Anti-Inflammatory Activity of Rhizoma coptidis Based on Fingerprints Combined with Chemometrics Methods.
Berberine, palmatine, coptisine, jateorrhizine and epiberberine were the main anti-inflammatory components on the basis of the quantitative determination of the six alkaloids and spectrum-effect investigation and the collecting time of R. coptidis impacted the plant's alkaloid contents and its anti- inflammatory activity. Expand
Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids.
Goenlandicine may be a promising anti-AD agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as marked ONOO(-) scavenging and good ROS inhibitory capacities. Expand
Interaction of palmatine with DNA: an environmentally controlled phototherapy drug.
This paper identifies via molecular dynamic techniques two stable interaction modes between palmatine and B-DNA, namely insertion and minor groove binding, whose structural and electronic bases are analyzed and rationalized and shows that these two competitive modes may indeed coexist. Expand
Atividade anticolinesterásica e perfil químico de uma fração cromatográfica ativa do extrato etanólico das flores Bellis perennis L. (Asteraceae)
This work describes the isolation of an active flavonoid fraction and identification of isorhamnetin 3-O-β-D-(6''-acetyl)-galactopyranoside from flowers of B. perennis, and also the evaluation ofExpand
Coptis chinensis alkaloids exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBP-α and PPAR-γ.
The present study found that the isolated alkaloids inhibited adipogenesis in a dose-dependent manner in 3T3-L1 cells; this inhibition was attributed to their abilities to downregulate the protein levels of the adipocyte marker proteins PPAR-γ and C/EBP-α. Expand
Chemical composition and antimicrobial activity of the essential oils of the Amazon Guatteriopsis species.
The essential oils of Guatteriopsis blepharophylla, G. friesiana and G. hispida were obtained by hydrodistillation and analysed by GC and GC/MS and the antimicrobial activity of the essential oils was evaluated against 11 species of microorganisms. Expand
In vitro inhibitory effects of palmatine from Enantia chlorantha on Trypanosoma cruzi and Leishmania infantum
In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated inExpand