Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway

@article{Guo2018PharmacologicalAO,
  title={Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway},
  author={Dong-kai Guo and Yao Hui Zhu and Hong-yang Sun and Xing-yun Xu and Shun Yao Zhang and Zong-bing Hao and Guang-hui Wang and Chen-chen Mu and Hai-gang Ren},
  journal={Acta Pharmacologica Sinica},
  year={2018},
  volume={40},
  pages={26-34}
}
REV-ERBα, the NR1D1 (nuclear receptor subfamily 1, group D, member 1) gene product, is a dominant transcriptional silencer that represses the expression of genes involved in numerous physiological functions, including circadian rhythm, inflammation, and metabolism, and plays a crucial role in maintaining immune functions. Microglia-mediated neuroinflammation is tightly associated with various neurodegenerative diseases and psychiatric disorders. However, the role of REV-ERBα in… CONTINUE READING
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