Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice.

@article{Miura2009PharmacologicalAO,
  title={Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice.},
  author={Pedro Miura and Joe V Chakkalakal and Louise Boudreault and Guy B{\'e}langer and Richard L. H{\'e}bert and J C Renaud and Bernard J. Jasmin},
  journal={Human molecular genetics},
  year={2009},
  volume={18 23},
  pages={4640-9}
}
A therapeutic strategy to treat Duchenne muscular dystrophy (DMD) involves identifying compounds that can elevate utrophin A expression in muscle fibers of affected patients. The dystrophin homologue utrophin A can functionally substitute for dystrophin when its levels are enhanced in the mdx mouse model of DMD. Utrophin A expression in skeletal muscle is regulated by mechanisms that promote the slow myofiber program. Since activation of peroxisome proliferator-activated receptor (PPAR) beta… CONTINUE READING

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