Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity

@article{Brenchat2010PharmacologicalAO,
  title={Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity},
  author={A. Brenchat and X. Nadal and L. Romero and S. Ovalle and E. Portillo-Salido and J. Vela},
  journal={PAIN},
  year={2010},
  volume={149},
  pages={483-494}
}
&NA; The involvement of the 5‐HT7 receptor in nociception and pain, particularly chronic pain (i.e., neuropathic pain), has been poorly investigated. In the present study, we examined whether the 5‐HT7 receptor participates in some modulatory control of nerve injury‐evoked mechanical hypersensitivity and thermal (heat) hyperalgesia in mice. Activation of 5‐HT7 receptors by systemic administration of the selective 5‐HT7 receptor agonist AS‐19 (1 and 10 mg/kg) exerted a clear‐cut reduction of… Expand
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References

SHOWING 1-10 OF 56 REFERENCES
5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice
  • 115
5-HT(1A) receptor activation: new molecular and neuroadaptive mechanisms of pain relief.
  • F. Colpaert
  • Medicine
  • Current opinion in investigational drugs
  • 2006
  • 82
Tissue Injury Regulates Serotonin 1D Receptor Expression: Implications for the Control of Migraine and Inflammatory Pain
  • 59
  • PDF
5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons.
  • 74
  • Highly Influential
Dual effect of serotonin on formalin-induced nociception in the rat spinal cord
  • 130
...
1
2
3
4
5
...