Pharmacological actions of thymol and an analogue at GABAB autoreceptors

@article{Parker2014PharmacologicalAO,
  title={Pharmacological actions of thymol and an analogue at GABAB autoreceptors},
  author={D. A. Parker and V. Marino and J. Ong},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2014},
  volume={41}
}
GABAB autoreceptors inhibit release of GABA from GABAergic nerve terminals. Agonists of these receptors (e.g. baclofen) inhibit, whereas antagonists (e.g. (+)‐(S)‐5,5‐dimethylmorpholinyl‐2‐acetic acid; Sch 50911) enhance release of the transmitter. The actions of thymol (2‐isopropyl‐5‐methylphenol) and the structurally related compound 2‐tert‐butyl‐4‐methylphenol, (4MP) on the release of [3H]‐GABA were examined in rat neocortical slices where the GABAergic nerves had been preloaded with [3H… Expand

References

SHOWING 1-10 OF 23 REFERENCES
Pharmacological actions of oximino‐propofol analogues at GABAB autoreceptors
The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor antagonist in rat neocortical slices.
gamma-aminobutyric acid(B) receptors: first of the functional metabotropic heterodimers.
  • N. Bowery, S. Enna
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 2000
Structural requirements of phenol derivatives for direct activation of chloride currents via GABA(A) receptors.
THE CGP7930 ANALOGUE 2,6‐DI‐TERT‐BUTYL‐4‐(3‐HYDROXY‐2‐SPIROPENTYLPROPYL)‐PHENOL (BSPP) POTENTIATES BACLOFEN ACTION AT GABAB AUTORECEPTORS
Clinical potential of GABAB receptor modulators.
A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system
GABA(A) receptor channel pharmacology.
  • G. Johnston
  • Biology, Medicine
  • Current pharmaceutical design
  • 2005
...
1
2
3
...