Pharmacological actions of the peptide hormone amylin in the long-term regulation of food intake, food preference, and body weight.

@article{Mack2007PharmacologicalAO,
  title={Pharmacological actions of the peptide hormone amylin in the long-term regulation of food intake, food preference, and body weight.},
  author={Christine M. Mack and Julie Wilson and Jennifer R Athanacio and James Reynolds and Kevin D. Laugero and Stacy Guss and Calvin Vu and Jonathan Roth and David C. Parkes},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2007},
  volume={293 5},
  pages={R1855-63}
}
The ability of amylin to reduce acute food intake in rodents is well established. Longer-term administration in rats (up to 24 days) shows a concomitant reduction in body weight, suggesting energy intake plays a significant role in mediating amylin-induced weight loss. The current set of experiments further explores the long-term effects of amylin (4-11 wk) on food preference, energy expenditure, and body weight and composition. Furthermore, we describe the acute effect of amylin on locomotor… CONTINUE READING

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