Pharmacological Study of IQM-97,423, a Potent and Selective CCK1 Receptor Antagonist with Protective Effect in Experimental Acute Pancreatitis

@article{Latorre2004PharmacologicalSO,
  title={Pharmacological Study of IQM-97,423, a Potent and Selective CCK1 Receptor Antagonist with Protective Effect in Experimental Acute Pancreatitis},
  author={M. Latorre and J. Bartolom{\'e}-Nebreda and M. Garc{\'i}a-L{\'o}pez and R. Gonz{\'a}lez-Mu{\~n}iz and R. Herranz and J. del R{\'i}o and E. Cenarruzabeitia},
  journal={Pharmacology},
  year={2004},
  volume={72},
  pages={68 - 76}
}
The pharmacological profile of the new CCK1 receptor antagonist IQM-97,423, (4aS,5R)-2-benzyl-5-(tert-butylaminocarbonyl-tryptophyl)amino-1,3-dioxoperhydropyrido-[1,2-c]pyrimidine, was examined in in vitro and in vivo studies and compared with typical CCK1 antagonists such as devazepide and lorglumide. IQM-97,423 showed a high affinity at [3H]-pCCK8-labeled rat pancreatic CCK1 receptors, and was virtually devoid of affinity at brain CCK2 receptors. IQM-97,423 antagonized CCK8S-stimulated… Expand
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