Pharmacological Studies with Vinblastine in the Dog

@article{Creasey1975PharmacologicalSW,
  title={Pharmacological Studies with Vinblastine in the Dog},
  author={William A. Creasey and A. I. Scott and Chuah Chin Wei and J Kutcher and Andrei Schwartz and John C. Marsh},
  journal={Cancer research},
  year={1975},
  volume={35 5},
  pages={1116-20}
}
Tritiated vinblastine was prepared by catalytic exchange and its metabolism was studied in dogs. Plasma levels of drug fell in biphasic mode with initial and secondary phase half-lives of 17 to 38 min and 3 to 5 hr, respectively. Between 28.6 and 79.1% of plasma tritium was precipitable with cold trichloroacetic acid and thus was presumably protein bound. Blood leukocytes had levels of intracellular tritium between 2.4 and 11.8 times those of the coincident plasma samples. Over a 9-day period… CONTINUE READING

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