Pharmacological Stimulation of the Cholinergic Antiinflammatory Pathway

  title={Pharmacological Stimulation of the Cholinergic Antiinflammatory Pathway},
  author={Thomas R. Bernik and Steven G. Friedman and Mahendar Ochani and Robert DiRaimo and L. Fernando Ulloa and H Yang and Samridhi Sudan and Christopher J. Czura and Svetlana M. Ivanova and Kevin J Tracey},
  journal={The Journal of Experimental Medicine},
  pages={781 - 788}
Efferent activity in the vagus nerve can prevent endotoxin-induced shock by attenuating tumor necrosis factor (TNF) synthesis. Termed the "cholinergic antiinflammatory pathway," inhibition of TNF synthesis is dependent on nicotinic alpha-bungarotoxin-sensitive acetylcholine receptors on macrophages. Vagus nerve firing is also stimulated by CNI-1493, a tetravalent guanylhydrazone molecule that inhibits systemic inflammation. Here, we studied the effects of pharmacological and electrical… CONTINUE READING
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