Pharmacological Reduction of Portal Pressure and Long-Term Risk of First Variceal Bleeding in Patients with Cirrhosis

@article{Turnes2006PharmacologicalRO,
  title={Pharmacological Reduction of Portal Pressure and Long-Term Risk of First Variceal Bleeding in Patients with Cirrhosis},
  author={Juan Turnes and Juan Carlos Garc{\'i}a-Pag{\'a}n and Juan G Abraldes and Manuel Hern{\'a}ndez-Guerra and Alessandra Dell'era and J Bosch},
  journal={The American Journal of Gastroenterology},
  year={2006},
  volume={101},
  pages={506-512}
}
OBJECTIVES:A reduction in hepatic venous pressure gradient (HVPG) of ≥20% of baseline or to ≤12 mmHg (responders) is associated with a reduced risk of first variceal bleeding. The aim of this study was to evaluate whether this protective effect is maintained in the long term and if it extends to other portal hypertension complications.METHODS:Seventy-one cirrhotic patients with esophageal varices and without previous variceal bleeding who entered into a program of prophylactic pharmacological… CONTINUE READING
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