Pharmacological Properties of Glycine Transport in the Frog Retina

@article{PrezLen2004PharmacologicalPO,
  title={Pharmacological Properties of Glycine Transport in the Frog Retina},
  author={Jorge Alberto P{\'e}rez-Le{\'o}n and Estuardo L{\'o}pez‐Vera and Roc{\'i}o Salceda},
  journal={Neurochemical Research},
  year={2004},
  volume={29},
  pages={313-318}
}
The high-affinity glycine transport in neurons and glial cells is the primary means for inactivating synaptic glycine. Two different glycine transporter genes, Glyt-1 and Glyt-2, have been cloned. Glyt-1 has been reported to occur in the retina, but there is no evidence for expression of the Glyt-2 transporter. We have pharmacologically characterized glycine transport in the frog retina. 3H-Glycine uptake in the retina was insensitive to modulation by phorbol esters or changes in cAMP levels… Expand
Pharmacological properties of glycine uptake in the developing rat retina
  • R. Salceda
  • Biology, Medicine
  • Neurochemistry International
  • 2006
TLDR
The results suggest that the Glyt1 transporter was concentrated in the nerve terminals of the retina, and provided evidence of the occurrence of Glyt2 and/or another isoform of glycine transporter, which might have had a role in the retina development. Expand
Glycine transporters (glycine transporter 1 and glycine transporter 2) are expressed in retina
TLDR
In-situ hybridization signals were observed in the ganglionar and inner nuclear layer as well as in the outer nuclear layer of the frog and rat retinas and accumulation of 3H-glycine was observed in isolated photoreceptor cells. Expand
Differential distribution of glycine transporters in Müller cells and neurons in amphibian retinas
TLDR
The results indicated that GlyT1- and GlyT2-like transporters were present in Müller cells and neurons, respectively, which is consistent with the general pattern that Gly T1-liketransporters are present in Muller cells and Gly T2- like transportters in neurons in amphibian retinas. Expand
Expression of glycine receptor and transporter on bullfrog retinal Müller cells
TLDR
Findings suggest that Müller cells may be involved in modulation of glycinergic transmission by reciprocal interactions with retinal neurons through GlyR and GlyT. Expand
Functional expression of the glycine transporter 1 on bullfrog retinal cones
TLDR
Results show for the first time the functional expression of GlyT1 on bullfrog cones in bullfrog retinal slices. Expand
Characterization of glycinergic synapses in vertebrate retinas.
TLDR
The function and mechanism of glycinergic synapses in retinas are described, and immunocytochemical studies identify glycine receptor subunits (alpha1, alpha2, alpha3 and beta) in retina, forming picrotoxin-sensitive alpha-homomeric and picroToxin-insensitive alpha/beta-heteromeric receptors. Expand
Glycine transport accounts for the differential role of glycine vs. d‐serine at NMDA receptor coagonist sites in the salamander retina
In this study, we demonstrate that d‐serine interacts with N‐methyl‐d‐aspartate receptor (NMDAR) coagonist sites of retinal ganglion cells of the tiger salamander retina by showing that exogenousExpand
Endogenous expression of the glycine transporter 2 in C6 glioma cells: a preliminary study
TLDR
Evidence that in addition to GlyT1, GlyT2 is also endogenously expressed in C6 glioma cells is provided, which will help researchers to carefully evaluate use of this cell line in studies involving GlyT 1. Expand
D-serine: A study of its function and regulation in the retina
University of Minnesota Ph.D. dissertation. Major: Neuroscience. Advisor: Robert F. Miller, MD. 1 computer file (PDF); v, 130 pages. Ill. (some col.)

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