• DOI:10.1124/jpet.110.167346
Corpus ID: 12893717

Pharmacological Profile of Lurasidone, a Novel Antipsychotic Agent with Potent 5-Hydroxytryptamine 7 (5-HT7) and 5-HT1A Receptor Activity

@article{Ishibashi2010PharmacologicalPO,
  title={Pharmacological Profile of Lurasidone, a Novel Antipsychotic Agent with Potent 5-Hydroxytryptamine 7 (5-HT7) and 5-HT1A Receptor Activity},
  author={T. Ishibashi and T. Horisawa and K. Tokuda and T. Ishiyama and M. Ogasa and R. Tagashira and Kenji Matsumoto and Hiroyuki Nishikawa and Y. Ueda and Satoko Toma and Hitomi Oki and N. Tanno and I. Saji and Akira Ito and Y. Ohno and Mitsutaka Nakamura},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2010},
  volume={334},
  pages={171 - 181}
}

• T. Ishibashi, T. Horisawa, +13 authors Mitsutaka Nakamura
• Published 2010
• Chemistry, Medicine
• Journal of Pharmacology and Experimental Therapeutics

Lurasidone [(3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl}hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; SM-13496] is an azapirone derivative and a novel antipsychotic candidate. The objective of the current studies was to investigate the in vitro and in vivo pharmacological properties of lurasidone. Receptor binding affinities of lurasidone and several antipsychotic drugs were tested under comparable assay conditions using cloned… Expand