Pharmacological Profile of Lurasidone, a Novel Antipsychotic Agent with Potent 5-Hydroxytryptamine 7 (5-HT7) and 5-HT1A Receptor Activity

@article{Ishibashi2010PharmacologicalPO,
  title={Pharmacological Profile of Lurasidone, a Novel Antipsychotic Agent with Potent 5-Hydroxytryptamine 7 (5-HT7) and 5-HT1A Receptor Activity},
  author={T. Ishibashi and T. Horisawa and K. Tokuda and T. Ishiyama and M. Ogasa and R. Tagashira and Kenji Matsumoto and Hiroyuki Nishikawa and Y. Ueda and Satoko Toma and Hitomi Oki and N. Tanno and I. Saji and Akira Ito and Y. Ohno and Mitsutaka Nakamura},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2010},
  volume={334},
  pages={171 - 181}
}
Lurasidone [(3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl}hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; SM-13496] is an azapirone derivative and a novel antipsychotic candidate. The objective of the current studies was to investigate the in vitro and in vivo pharmacological properties of lurasidone. Receptor binding affinities of lurasidone and several antipsychotic drugs were tested under comparable assay conditions using cloned… Expand
Binding of lurasidone, a novel antipsychotic, to rat 5-HT7 receptor: Analysis by [3H]SB-269970 autoradiography
The Role of 5-Hydroxytryptamine 7 Receptors in the Phencyclidine-Induced Novel Object Recognition Deficit in Rats
Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands.
Pharmacology profile of F17464, a dopamine D3 receptor preferential antagonist.
The Novel Antipsychotic Drug Lurasidone Enhances N-Methyl-d-aspartate Receptor-Mediated Synaptic Responses
Structural insight into receptor-selectivity for lurasidone
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 63 REFERENCES
Pharmacological actions of SM-9018, a new neuroleptic drug with both potent 5-hydroxytryptamine2 and dopamine2 antagonistic actions.
The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent.
Pharmacological properties of SM-3997: a new anxioselective anxiolytic candidate.
Serotonin receptors : their key role in drugs to treat schizophrenia
Binding profile of SM-9018, a novel antipsychotic candidate.
Lurasidone: a new drug in development for schizophrenia
GABAergic modulation of 5-HT7 receptor-mediated effects on 5-HT efflux in the guinea-pig dorsal raphe nucleus
...
1
2
3
4
5
...