Pharmacological Profile of Lurasidone, a Novel Antipsychotic Agent with Potent 5-Hydroxytryptamine 7 (5-HT7) and 5-HT1A Receptor Activity

@article{Ishibashi2010PharmacologicalPO,
  title={Pharmacological Profile of Lurasidone, a Novel Antipsychotic Agent with Potent 5-Hydroxytryptamine 7 (5-HT7) and 5-HT1A Receptor Activity},
  author={T. Ishibashi and Tomoko Horisawa and K. Tokuda and T. Ishiyama and M. Ogasa and Rie Tagashira and K. Matsumoto and H. Nishikawa and Y. Ueda and S. Toma and Hitomi Oki and Norihiko Tanno and I. Saji and A. Ito and Y. Ohno and M. Nakamura},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2010},
  volume={334},
  pages={171 - 181}
}
  • T. Ishibashi, Tomoko Horisawa, +13 authors M. Nakamura
  • Published 2010
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
  • Lurasidone [(3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl}hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; SM-13496] is an azapirone derivative and a novel antipsychotic candidate. The objective of the current studies was to investigate the in vitro and in vivo pharmacological properties of lurasidone. Receptor binding affinities of lurasidone and several antipsychotic drugs were tested under comparable assay conditions using cloned… CONTINUE READING
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