Pharmacological Modulation of Cardiovascular Remodeling: A Guide to Heart Failure Therapy

  title={Pharmacological Modulation of Cardiovascular Remodeling: A Guide to Heart Failure Therapy},
  author={Willem J. Remme},
  journal={Cardiovascular Drugs and Therapy},
Cardiac remodeling is a complex process, which involves genetic, molecular and cellular changes in cardiomyocytes and the interstitium, leading to progressive structural and functional alterations, including cardiac dilatation, interstitial fibrosis, and a reduction in contractility and relaxation. As cardiac function worsens, ventricular dysfunction, heart failure and end-stage heart disease are the ultimate consequences. Underlying mechanisms include myocardial stretch and neurohormonal and… CONTINUE READING


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