Pharmacological Management of Essential Tremor

@article{Sadeghi2012PharmacologicalMO,
  title={Pharmacological Management of Essential Tremor},
  author={Reza Sadeghi and William G Ondo},
  journal={Drugs},
  year={2012},
  volume={70},
  pages={2215-2228}
}
Essential tremor (ET) is a common movement disorder with clinical features that manifest with both motor (tremor and balance disorders) and non-motor (such as mild cognitive deficits and hearing loss) symptoms. The diagnosis of ET is based on the presence of an action tremor of greater severity than enhanced physiological tremor, without other identifiable causes. Patients with ET experience a decrease in the performance of their motor skills and social activities, and a decline in their… Expand
17 Citations
Nursing Management of the Patient Undergoing Focused Ultrasound: A New Treatment Option for Essential Tremor.
TLDR
In a large academic medical center in the mid-Atlantic region, the Department of Neurosurgery conducted a continued access study to evaluate the effectiveness of transcranial FUS thalamotomy for the treatment of medication-refractory ET. Expand
Botulinum Toxin Type A Injections as Monotherapy for Upper Limb Essential Tremor Using Kinematics
TLDR
Individualized BoNT-A dosing patterns to each individual’s tremor biomechanics provided an effective monotherapy for ET as function improved without functionally limiting muscle weakness. Expand
Current and Emerging Treatments of Essential Tremor.
  • W. Ondo
  • Medicine
  • Neurologic clinics
  • 2020
TLDR
A number of investigational medications, including T-type calcium channel blockers and allosteric gamma-aminobutyric acid-A modulators, are being developed for tremor. Expand
Could Wearable and Mobile Technology Improve the Management of Essential Tremor?
  • J. Daneault
  • Computer Science, Medicine
  • Front. Neurol.
  • 2018
TLDR
Seven different areas within which mobile and wearable technology may improve the clinical management of essential tremor are proposed and the current state of research in these areas is reviewed. Expand
Pharmacological Treatments of Tremor
This chapter discusses the drugs used in the treatment of tremor and provides a pharmacological therapeutical approach for the management of the main neurological disorders characterized by tremor.Expand
Higher prevalence of migraine in essential tremor: A case–control study
TLDR
It is suggested that essential tremor patients have a higher risk of lifetime migraine than do controls and the dopamine receptor D3 Ser9Gly variant may be lower inessential tremor with migraine than the general essential tre MOR patients. Expand
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This study described the first case of isolated massive choroidal detachment induced by topiramate, a 79-year-old male admitted to the authors' center due to acute bilateral painless decline of vision, which was described as a potential causative agent for this condition. Expand
A Practitioner’s Guide to Prescribing Primidone for Adults with Intellectual Disabilities
TLDR
This primidone guideline provides a useful resource for clinicians who treat epilepsy in adult individuals with intellectual disabilities and may not fully account for all of the possible risks of treatment in this population because of the limited studies available. Expand
A Practitioner’s Guide to Prescribing Pregabalin for Adults with Intellectual Disabilities
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This guideline includes indications, contraindications, assessments prior to and during treatment, dosing with particular focus on dosing modifications required by drug–drug interactions or personal characteristics, and adverse drug reactions. Expand
Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline‐induced Model of Essential Tremor in Rats
The aim of the study was to examine the effects of preferential agonists of dopamine D3 receptors: pramipexole and 7‐OH‐DPAT on the harmaline‐induced tremor in rats (a model of essential tremor, ET).Expand
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TLDR
Additional prospective, double-blind, placebo-controlled trials are needed to better determine the efficacy and side effects of pharmacologic and surgical treatments of ET. Expand
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TLDR
Although a positive family history, alcohol sensitivity, and propranolol responsiveness are characteristic of ET, these factors should not be considered necessary for the diagnosis of ET. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
The results suggest that in selected drug‐resistant ET cases, clozapine should be considered before resorting to neurosurgical options, as it effectively reduced tremor in 13 of 15 patients. Expand
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TLDR
The treatment of essential tremor depends on the tremor severity, location, and risk benefit ratios, but there is support for polypharmacy in some cases. Expand
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TLDR
Results suggest that mild cognitive deficits are not uncommon in association with severe ET and may be related to subcortical systems, as seen in Parkinson's disease. Expand
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