Pharmacological MRI combined with electrophysiology in non-human primates: Effects of Lidocaine on primary visual cortex

@article{Rauch2008PharmacologicalMC,
  title={Pharmacological MRI combined with electrophysiology in non-human primates: Effects of Lidocaine on primary visual cortex},
  author={Alexander Rauch and Gregor Rainer and Mark Augath and Axel Oeltermann and Nikos K. Logothetis},
  journal={NeuroImage},
  year={2008},
  volume={40 2},
  pages={590-600}
}
Pharmacological magnetic resonance imaging (phMRI) is a current direction in biomedical imaging, whose goal is the non-invasive monitoring of pharmacological manipulations on brain processes. We have developed techniques combining phMRI with simultaneous monitoring of electrophysiological activity during local injections of pharmacological agents into defined brain regions. We have studied effects of the local anesthetic Lidocaine on BOLD activity in primary visual cortex (V1) of non-human… CONTINUE READING