Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.

@article{Pirinen2014PharmacologicalIO,
  title={Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.},
  author={Eija Pirinen and Carles Cant{\'o} and Young Suk Jo and L N S Morato and Hongbo Zhang and Keir Joe Menzies and Evan G Williams and Laurent Mouchiroud and Norman Moullan and Carolina E. Hagberg and Wei Li and S. Timmers and Ralph Imhof and Jef Verbeek and Aurora Pujol and Barbara van Loon and Carlo Viscomi and Massimo Zeviani and Patrick Schrauwen and Anthony A. Sauve and Kristina Schoonjans and Johan Auwerx},
  journal={Cell metabolism},
  year={2014},
  volume={19 6},
  pages={1034-41}
}
We previously demonstrated that the deletion of the poly(ADP-ribose)polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity. However, the therapeutic use of PARP inhibitors to enhance mitochondrial function remains to be explored. Here, we show tight negative correlation between Parp-1 expression and energy expenditure in heterogeneous mouse populations, indicating that variations in PARP-1 activity have an impact on metabolic homeostasis… CONTINUE READING
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Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle, Cell Metabolism

  • Pirinen
  • 2014
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