Pharmacological Evidence for a Motivational Role of κ-Opioid Systems in Ethanol Dependence

@article{Walker2008PharmacologicalEF,
  title={Pharmacological Evidence for a Motivational Role of $\kappa$-Opioid Systems in Ethanol Dependence},
  author={Brendan M Walker and George F. Koob},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={643-652}
}
  • B. WalkerG. Koob
  • Published 1 February 2008
  • Medicine, Biology
  • Neuropsychopharmacology
The purpose of this study was to test the hypothesis that activation of the dynorphin/kappa (κ)-opioid system has a role in the increased consumption of ethanol in dependent animals. The effects of three opioid receptor antagonists with different effects on opioid receptors, naltrexone, nalmefene, and nor-binaltorphimine (nor-BNI), were compared in their ability to decrease ethanol self-administration in nondependent and ethanol-dependent male Wistar rats. Nalmefene and naltrexone are both… 

nor-BNI Antagonism of Kappa Opioid Agonist-Induced Reinstatement of Ethanol-Seeking Behavior

Results suggest that activation of KORs is a key mechanism in the regulation of ethanol-seeking behavior, but U50,488-induced reinstatement may not be fully selective for K ORs.

Involvement of dynorphin and kappa opioid receptor in yohimbine‐induced reinstatement of heroin seeking in rats

The present experiments suggest that the stress responsive ppDyn/KOP-r system is a critical component of the neural circuitry underlying the effect of yohimbine stress on heroin seeking behavior and HPA activity.

Species differences in the effects of the κ-opioid receptor antagonist zyklophin.

The κ-opioid receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats

It is suggested that κ-opioid receptor antagonists may be a valuable adjunct in the pharmacotherapy of ethanol use disorders and that accumbal λ-opIOid receptors participate in the modulation of the reinforcing effects of ethanol.

Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H.

...

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