Pharmacological Evidence for a Motivational Role of κ-Opioid Systems in Ethanol Dependence

@article{Walker2008PharmacologicalEF,
  title={Pharmacological Evidence for a Motivational Role of $\kappa$-Opioid Systems in Ethanol Dependence},
  author={B. Walker and G. Koob},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={643-652}
}
The purpose of this study was to test the hypothesis that activation of the dynorphin/kappa (κ)-opioid system has a role in the increased consumption of ethanol in dependent animals. The effects of three opioid receptor antagonists with different effects on opioid receptors, naltrexone, nalmefene, and nor-binaltorphimine (nor-BNI), were compared in their ability to decrease ethanol self-administration in nondependent and ethanol-dependent male Wistar rats. Nalmefene and naltrexone are both… Expand

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