Pharmacological Effects of Rutaecarpine as a Cardiovascular Protective Agent

@article{Jia2010PharmacologicalEO,
  title={Pharmacological Effects of Rutaecarpine as a Cardiovascular Protective Agent},
  author={Sujie Jia and Changping Hu},
  journal={Molecules},
  year={2010},
  volume={15},
  pages={1873 - 1881}
}
Many studies indicate that traditional Chinese herbs are beneficial in the prevention and treatment of cardiovascular diseases. Evodia rutaecarpa (‘Wu-Chu-Yu’) remains the most popular and multi-purpose herb traditionally used in China for treatment of headache, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea. Rutaecarpine is one of the intriguing indolopyridoquinazoline alkaloids isolated from ‘Wu-Chu-Yu’. Rutaecarpine has been shown to have cardiovascular biological effects… 
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Rutaecarpine: A promising cardiovascular protective alkaloid from Evodia rutaecarpa (Wu Zhu Yu).
Re-Purposing Evodiamine as an Anti-CancerDrug: Effects on Migration and Apoptosis
TLDR
The goal of this study was to determine the feasibility of re-purposing evodiamine as an anti-cancer drug and to test the necessary concentrations to achieve possible clinical results through oral administration.
Rutaecarpine effects on expression of hepatic phase-1, phase-2 metabolism and transporter genes as a basis of herb-drug interactions.
Mechanism-based inhibition of CYPs and RMs-induced hepatoxicity by rutaecarpine
TLDR
Rutaecarpine can inhibit the activities of CYPs and exhibit a potential mechanism-based inhibition on CYP1A2, and may cause herb–drug interactions, providing important information for predicting drug-induced hepatotoxicity.
Dual-targeting Rutaecarpine-NO donor hybrids as novel anti-hypertensive agents by promoting release of CGRP.
O-prenylated flavonoid, an antidiabetes constituent in Melicope lunu-ankenda.
Synthetic Fluororutaecarpine Inhibits Inflammatory Stimuli and Activates Endothelial Transient Receptor Potential Vanilloid-Type 1
TLDR
The results suggest that the novel synthetic F-RUT exerts activities against inflammation and vasodilation, while displaying less toxicity than its lead compound.
Identification of evodiamine as the bioactive compound in evodia (Evodia rutaecarpa Benth.) fruit extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ).
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis
TLDR
RUT alleviated the gross gastric damage, ulcer index and the histopathology damage caused by ethanol and exerted a gastroprotective effect against gastric mucosal injury induced by ethanol, and improved the antioxidant milieu by remarkably upregulate antioxidant SOD, GSH, CAT and downregulate levels of MDA.
Vasorelaxant activity of indole alkaloids from Tabernaemontana dichotoma
TLDR
The methanol extract from bark of Tabernaemontana dichotoma showed vasorelaxant activity on rat aorta and mechanism of action of 10-methoxyaffinisine (2), cathafoline (4), and alstonisine (7) was clarified.
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References

SHOWING 1-10 OF 46 REFERENCES
Progress in the Studies on Rutaecarpine
TLDR
Recent progress in the studies on the isolation, synthesis, structure-activity relationship studies, biological activities and metabolism of rutaecarpine are reviewed.
Anti-inflammatory principles from the fruits ofEvodia rutaecarpa and their cellular action mechanisms
TLDR
From the results, evodiamine and rutaecarpine were found to strongly inhibit prostaglandin E2 synthesis from lipopolysaccharide-treated RAW 2647 cells at 1–10 μM, and these pharmacological properties may provide the additional scientific rationale for anti-inflammatory use of the fruits of E. rutaECarpa.
Studies of the cellular mechanisms underlying the vasorelaxant effects of rutaecarpine, a bioactive component extracted from an herbal drug.
TLDR
Results suggest that these vasorelaxants had different cellular mechanisms and that neither pertussis toxin-sensitive Gi protein, other G proteins, nor phospholipase C activation was involved in the cellular response to rutaecarpine.
Calcitonin gene-related peptide-mediated antihypertensive and anti-platelet effects by rutaecarpine in spontaneously hypertensive rats
Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa.
TLDR
It is demonstrated that quinazoline alkaloids isolated from Evodia rutaecarpa, to aorta smooth muscle demonstrated that they produce a vasodilatory effect on endothelium-intact rat aortA with equal potency.
Synthesis and vasodilator effects of rutaecarpine analogues which might be involved transient receptor potential vanilloid subfamily, member 1 (TRPV1).
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Evodiamine and rutaecarpine inhibit migration by LIGHT via suppression of NADPH oxidase activation
TLDR
The inhibitory effects of evodiamine and rutaecarpine on LIGHT‐induced migration and the activation of CCR1, CCR2, ICAM‐1, ERK, and p38 MAPK occurs via decreased ROS production and NADPH oxidase activation.
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TLDR
Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae).
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