Pharmacological Effects of Rutaecarpine as a Cardiovascular Protective Agent

@article{Jia2010PharmacologicalEO,
  title={Pharmacological Effects of Rutaecarpine as a Cardiovascular Protective Agent},
  author={Sujie Jia and Changping Hu},
  journal={Molecules},
  year={2010},
  volume={15},
  pages={1873 - 1881}
}
Many studies indicate that traditional Chinese herbs are beneficial in the prevention and treatment of cardiovascular diseases. Evodia rutaecarpa (‘Wu-Chu-Yu’) remains the most popular and multi-purpose herb traditionally used in China for treatment of headache, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea. Rutaecarpine is one of the intriguing indolopyridoquinazoline alkaloids isolated from ‘Wu-Chu-Yu’. Rutaecarpine has been shown to have cardiovascular biological effects… 
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References

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Progress in the Studies on Rutaecarpine
TLDR
Recent progress in the studies on the isolation, synthesis, structure-activity relationship studies, biological activities and metabolism of rutaecarpine are reviewed.
Anti-inflammatory principles from the fruits ofEvodia rutaecarpa and their cellular action mechanisms
TLDR
From the results, evodiamine and rutaecarpine were found to strongly inhibit prostaglandin E2 synthesis from lipopolysaccharide-treated RAW 2647 cells at 1–10 μM, and these pharmacological properties may provide the additional scientific rationale for anti-inflammatory use of the fruits of E. rutaECarpa.
Studies of the cellular mechanisms underlying the vasorelaxant effects of rutaecarpine, a bioactive component extracted from an herbal drug.
TLDR
Results suggest that these vasorelaxants had different cellular mechanisms and that neither pertussis toxin-sensitive Gi protein, other G proteins, nor phospholipase C activation was involved in the cellular response to rutaecarpine.
Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa.
TLDR
It is demonstrated that quinazoline alkaloids isolated from Evodia rutaecarpa, to aorta smooth muscle demonstrated that they produce a vasodilatory effect on endothelium-intact rat aortA with equal potency.
Evodiamine and rutaecarpine inhibit migration by LIGHT via suppression of NADPH oxidase activation
TLDR
The inhibitory effects of evodiamine and rutaecarpine on LIGHT‐induced migration and the activation of CCR1, CCR2, ICAM‐1, ERK, and p38 MAPK occurs via decreased ROS production and NADPH oxidase activation.
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TLDR
Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae).
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