Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control

@article{Hu2018PharmacologicalEA,
  title={Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control},
  author={Tongyuan Hu and Zhongli Yang and Ming Li},
  journal={Journal of Neuroimmune Pharmacology},
  year={2018},
  volume={13},
  pages={453-466}
}
Beyond promoting smoking initiation and preventing smokers from quitting, nicotine can reduce food intake and body weight and thus is viewed as desirable by some smokers, especially many women. During the last several decades, the molecular mechanisms underlying the inverse correlation between smoking and body weight have been investigated extensively in both animals and humans. Nicotine’s weight effects appear to result especially from the drug’s stimulation of α3β4 nicotine acetylcholine… Expand
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References

SHOWING 1-10 OF 195 REFERENCES
Effect of Short-Term Cigarette Smoke Exposure on Body Weight, Appetite and Brain Neuropeptide Y in Mice
TLDR
Investigating how cigarette smoking affects body weight, food intake, plasma leptin concentration, hypothalamic NPY peptide, adipose mass and mRNA expression of uncoupling proteins (UCP), and tumor necrosis factor (TNF) α in mice found short-term cigarette smoke exposure led to reduced body weight and food intake. Expand
Nicotine Decreases Food Intake Through Activation of POMC Neurons
TLDR
It is demonstrated that nicotine decreases food intake and body weight by influencing the hypothalamic melanocortin system and identifies critical molecular and synaptic mechanisms involved in nicotine-induced decreases in appetite. Expand
Regulation of feeding-associated peptides and receptors by nicotine
TLDR
Current understanding of the regulatory effects of nicotine on the food intake and energy expenditure as related to the expression levels of leptin, NPY, orexin, uncoupling proteins, and of NPY and Orexin receptors is summarized. Expand
Evidence for the role of β2* nAChR desensitization in regulating body weight in obese mice
TLDR
Results indicate that β2 containing nAChRs are essential to SAZ-A's inhibitory effect on body weight and food intake and engage the melanocortin system. Expand
Molecules and circuits involved in nicotine addiction: The many faces of smoking
TLDR
Leveraging the knowledge from studies of different behaviors mediated by nicotine receptors in multiple brain circuits could provide points of convergence that will inform future therapeutic development for smoking cessation. Expand
Plasma neuropeptide Y levels relate cigarette smoking and smoking cessation to body weight regulation
Loss and disproportionate gain of body weight often seen respectively in smokers and quitters are believed to be due to disrupted energy homeostasis induced by nicotine, the major constituent ofExpand
Effects of cigarette smoke exposure and its cessation on body weight, food intake and circulating leptin, and ghrelin levels in the rat.
TLDR
Circulating leptin could not explain by its own BW and FIR changes during the first few week of CSE in rats, in contrast to the rest of the CSE period as well as after its cessation. Expand
Cigarette Smoking and Brain Regulation of Energy Homeostasis
TLDR
Nicotine exposure from cigarette smoke can change brain feeding regulation to reduce appetite via both energy homeostatic and reward mechanisms, causing a negative energy state which is characterized by reduced energy intake and increased energy expenditure that are linked to low body weight. Expand
Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase
TLDR
It is demonstrated that nicotine-induced weight loss is associated with inactivation of hypothalamic AMPK, decreased orexigenic signaling in the hypothalamus, increased energy expenditure as a result of increased locomotor activity, increased thermogenesis in brown adipose tissue (BAT), and alterations in fuel substrate utilization. Expand
Nicotinic regulation of energy homeostasis.
  • M. Zoli, M. Picciotto
  • Psychology, Medicine
  • Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • 2012
TLDR
The primary anatomical and functional features of the input, output, and central integration structures of the neuroendocrine systems that regulate energy homeostasis are described and the nAChR subtypes expressed in these structures in mammals are described to identify the possible molecular targets for nicotine. Expand
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