Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control

  title={Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control},
  author={Tongyuan Hu and Zhongli Yang and Ming D. Li},
  journal={Journal of Neuroimmune Pharmacology},
Beyond promoting smoking initiation and preventing smokers from quitting, nicotine can reduce food intake and body weight and thus is viewed as desirable by some smokers, especially many women. During the last several decades, the molecular mechanisms underlying the inverse correlation between smoking and body weight have been investigated extensively in both animals and humans. Nicotine’s weight effects appear to result especially from the drug’s stimulation of α3β4 nicotine acetylcholine… 

The Effect of Smoking Cessation on Body Weight and Other Metabolic Parameters with Focus on People with Type 2 Diabetes Mellitus

Smokers with diabetes mellitus substantially lower their risks of microvascular and macrovascular diabetic complications, in particular cardiovascular disease, by quitting smoking. However,

Understanding the role of smoking and chronic excess alcohol consumption on reduced caloric intake and the development of sarcopenia

A narrative review provides mechanistic insight into the biological link between smoking and/or chronic excess alcohol consumption, and increased risk of developing sarcopenia, and the implementation of behavioural change interventions and health policies regarding smoking and alcohol intake habits may mitigate the clinical and financial burden of sarc Openia on the healthcare system.

Effect of Cigarette Smoke on Gut Microbiota: State of Knowledge

The current knowledge about the mechanistic interaction between cigarette smoke and intestinal microbiota dysbiosis is reviewed, the likely actions of nicotine, aldehydes, polycyclic aromatic hydrocarbons, heavy metals, volatile organic compounds and toxic gases are reviewed, and the potential mechanisms of the lung–gut cross talk and skin-gutcross talk in regulating the balance of intestinal microbiota are revealed.

[Nutritional problems in smokers and passive smokers].

The worse nutritional status of smokers can contribute to the appearance/worsening of various diseases associated with smoking (cardiovascular, cancer, cataracts, osteoporosis, etc); therefore, nutritional surveillance and correction of nutritional deficiencies could represents health benefits for smokers and passive smokers, which should be considered in the future.

Behavioural Patterns and Growth Performance of Male Wistar Rats Exposed to Cigarette Smoke: Effects of Curcumin and Hesperidin

It is submitted that CS exposure negatively impacts on the growth performance and behavioural patterns and the potentials of curcumin and hesperidin in addressing these CS-provoked changes are demonstrated.

The Association of Olfactory Function with BMI, Appetite, and Prospective Weight Change in Dutch Community-Dwelling Older Adults

Lower olfactory function scores were associated with lower BMI in community-dwelling older adults who smoke, but not with appetite or prospective weight change, suggesting smoking older adults with olfactor impairments may pose as a vulnerable group with respect to developing undernutrition.

Variable Selection for Assessing Risk Factors for Weight and Body fat Gain During the First Year After Kidney Transplantation

13 potentially relevant risk factors for post-transplant weight/fat gain are identified: age, gender, genes, income, ethnicity, education, eating habits, physical activity, smoking cessation, baseline BMI, baseline fat, depression and perceived overall wellbeing.



Effect of Short-Term Cigarette Smoke Exposure on Body Weight, Appetite and Brain Neuropeptide Y in Mice

Investigating how cigarette smoking affects body weight, food intake, plasma leptin concentration, hypothalamic NPY peptide, adipose mass and mRNA expression of uncoupling proteins (UCP), and tumor necrosis factor (TNF) α in mice found short-term cigarette smoke exposure led to reduced body weight and food intake.

Nicotine Decreases Food Intake Through Activation of POMC Neurons

It is demonstrated that nicotine decreases food intake and body weight by influencing the hypothalamic melanocortin system and identifies critical molecular and synaptic mechanisms involved in nicotine-induced decreases in appetite.

Regulation of feeding-associated peptides and receptors by nicotine

Current understanding of the regulatory effects of nicotine on the food intake and energy expenditure as related to the expression levels of leptin, NPY, orexin, uncoupling proteins, and of NPY and Orexin receptors is summarized.

Molecules and circuits involved in nicotine addiction: The many faces of smoking

Effects of cigarette smoke exposure and its cessation on body weight, food intake and circulating leptin, and ghrelin levels in the rat.

Circulating leptin could not explain by its own BW and FIR changes during the first few week of CSE in rats, in contrast to the rest of the CSE period as well as after its cessation.

Cigarette Smoking and Brain Regulation of Energy Homeostasis

Nicotine exposure from cigarette smoke can change brain feeding regulation to reduce appetite via both energy homeostatic and reward mechanisms, causing a negative energy state which is characterized by reduced energy intake and increased energy expenditure that are linked to low body weight.

Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase

It is demonstrated that nicotine-induced weight loss is associated with inactivation of hypothalamic AMPK, decreased orexigenic signaling in the hypothalamus, increased energy expenditure as a result of increased locomotor activity, increased thermogenesis in brown adipose tissue (BAT), and alterations in fuel substrate utilization.

Nicotinic regulation of energy homeostasis.

  • M. ZoliM. Picciotto
  • Biology
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • 2012
The primary anatomical and functional features of the input, output, and central integration structures of the neuroendocrine systems that regulate energy homeostasis are described and the nAChR subtypes expressed in these structures in mammals are described to identify the possible molecular targets for nicotine.