Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone

@inproceedings{PerezAlvarez2012PharmacologicalCO,
  title={Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone},
  author={Sergio Perez-Alvarez and Mar{\'i}a E Solesio and Mar{\'i}a Dolores Cuenca-L{\'o}pez and Raquel Mar{\'i}a Melero-Fernandez de Mera and Carlos Villalobos and Hanna Kmita and Mar{\'i}a F. Galindo and J. A. Jordan},
  booktitle={International journal of cell biology},
  year={2012}
}
Previously, we have shown that SH-SY5Y cells exposed to high concentrations of methadone died due to a necrotic-like cell death mechanism related to delayed calcium deregulation (DCD). In this study, we show that, in terms of their Ca(2+) responses to 0.5 mM methadone, SH-SY5Y cells can be pooled into four different groups. In a broad pharmacological survey… CONTINUE READING