Pharmacological Characterization of cGMP Regulation by the Biarylpropylsulfonamide Class of Positive, Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors

@article{Ryder2006PharmacologicalCO,
  title={Pharmacological Characterization of cGMP Regulation by the Biarylpropylsulfonamide Class of Positive, Allosteric Modulators of $\alpha$-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors},
  author={John W. Ryder and Julie F. Falcone and Jason R. Manro and Kjell A. Svensson and Kalpana Mahesh Merchant},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={319},
  pages={293 - 298}
}
The biarylpropylsulfonamide class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) potentiators represented by N-2-(4-(4-cyanophenol)phenol)propyl-2-propanesulfonamide (LY404187) and (R)-4′-[1-fluoro-1-methyl-2-(propane-2-sulfonylamino)-ethyl]-biphenyl-4-carboxylic acid methylamide (LY503430) are positive, allosteric AMPA receptor activators, which enhance AMPA receptor-mediated neurotransmission by reducing desensitization of the ion channel. Although these compounds have… 

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