Pharmacological Characterization of Novel Water-Soluble Cannabinoids

  title={Pharmacological Characterization of Novel Water-Soluble Cannabinoids},
  author={B. Martin and J. Wiley and I. Beletskaya and L. Sim-Selley and F. Smith and W. Dewey and J. Cottney and Julia Adams and J. Baker and D. Hill and B. Saha and John Zerkowski and A. Mahadevan and R. Razdan},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={1230 - 1239}
  • B. Martin, J. Wiley, +11 authors R. Razdan
  • Published 2006
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • Presently, there are numerous structural classes of cannabinoid receptor agonists, all of which require solubilization for experimental purposes. One strategy for solubilizing water-insoluble tetrahydrocannabinols is conversion of the phenolic hydroxyl to a morpholinobutyryloxy substituent. The hydrochloride salts of these analogs are water-soluble and active in vivo when administered in saline. The present investigation demonstrated that hydrochloride salts of numerous substituted butyryloxy… CONTINUE READING
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