Pharmacological Characterization of Novel Water-Soluble Cannabinoids

@article{Martin2006PharmacologicalCO,
  title={Pharmacological Characterization of Novel Water-Soluble Cannabinoids},
  author={Billy R. Martin and Jenny L. Wiley and Irina Beletskaya and L. J. Sim-Selley and Forrest L. Smith and William L. Dewey and Jean E. Cottney and Julia Adams and J Baker and David Zack Hill and Bijali Saha and Jonathan A. Zerkowski and A. P. Mahadevan and Raj Kumar Razdan},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={318},
  pages={1230 - 1239}
}
  • B. Martin, J. Wiley, +11 authors R. Razdan
  • Published 1 September 2006
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
Presently, there are numerous structural classes of cannabinoid receptor agonists, all of which require solubilization for experimental purposes. One strategy for solubilizing water-insoluble tetrahydrocannabinols is conversion of the phenolic hydroxyl to a morpholinobutyryloxy substituent. The hydrochloride salts of these analogs are water-soluble and active in vivo when administered in saline. The present investigation demonstrated that hydrochloride salts of numerous substituted butyryloxy… 
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