Pharmacological Characterization of Noroxymorphone as a New Opioid for Spinal Analgesia

  title={Pharmacological Characterization of Noroxymorphone as a New Opioid for Spinal Analgesia},
  author={K. Lemberg and A. Siiskonen and V. Kontinen and J. Yli-Kauhaluoma and E. Kalso},
  journal={Anesthesia & Analgesia},
  • K. Lemberg, A. Siiskonen, +2 authors E. Kalso
  • Published 2008
  • Medicine
  • Anesthesia & Analgesia
  • BACKGROUND:Noroxymorphone is one of the major metabolites of oxycodone. Although oxycodone is commonly used in the treatment of acute and chronic pain, little is known about the antinociceptive effects of noroxymorphone. We present an in vivo pharmacological characterization of noroxymorphone in rats. METHODS:The antinociceptive properties of noroxymorphone were studied with thermal and mechanical models of nociception in rats. RESULTS:Intrathecal noroxymorphone (1 and 5 &mgr;g/10 &mgr;L… CONTINUE READING
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