Pharmacological Characterization of Noroxymorphone as a New Opioid for Spinal Analgesia

@article{Lemberg2008PharmacologicalCO,
  title={Pharmacological Characterization of Noroxymorphone as a New Opioid for Spinal Analgesia},
  author={Kim K. Lemberg and Antti O Siiskonen and Vesa Kontinen and Jari T Yli-Kauhaluoma and Eija A Kalso},
  journal={Anesthesia \& Analgesia},
  year={2008},
  volume={106},
  pages={463-470}
}
BACKGROUND:Noroxymorphone is one of the major metabolites of oxycodone. Although oxycodone is commonly used in the treatment of acute and chronic pain, little is known about the antinociceptive effects of noroxymorphone. We present an in vivo pharmacological characterization of noroxymorphone in rats. METHODS:The antinociceptive properties of noroxymorphone were studied with thermal and mechanical models of nociception in rats. RESULTS:Intrathecal noroxymorphone (1 and 5 &mgr;g/10 &mgr;L… 

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