Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist

  title={Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist},
  author={Kimberly E. Vanover and Scott C. Harvey and Thomas Son and Stefania Risso Bradley and Henriette Kold and Malath M. Makhay and Isaac Veinbergs and Tracy A. Spalding and David M Weiner and Carl Magnus Andersson and Bo Ragnar. Tolf and Mark R. Brann and Uli Hacksell and Robert E Davis},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={943 - 951}
The primary purpose of the present series of experiments was to characterize the in vitro and in vivo pharmacology profile of 2-(4-methoxy-phenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride (AC-90179), a selective serotonin (5-HT2A) receptor inverse agonist, in comparison with the antipsychotics haloperidol and clozapine. The secondary purpose was to characterize the pharmacokinetic profile of AC-90179. Like all atypical antipsychotics, AC-90179 shows high potency… 

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