Pharmacological Analysis of Human D1 and D2 Dopamine Receptor Missense Variants

  title={Pharmacological Analysis of Human D1 and D2 Dopamine Receptor Missense Variants},
  author={Munya A. Al-Fulaij and Yong Ren and Martin Beinborn and Alan S. Kopin},
  journal={Journal of Molecular Neuroscience},
Drugs targeting dopamine receptors have been the focus of much research over the past 30 years, in large part because of their role in treating multiple pathological conditions including Parkinson’s disease, schizophrenia, Tourette’s syndrome, and hyperprolactinemia. Missense mutations in G protein-coupled receptors (GPCRs) can alter basal and/or ligand-induced signaling, which in turn can affect individuals’ susceptibility to disease and/or response to therapeutics. To date, five coding… CONTINUE READING
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