Pharmacological Agents That Directly Modulate Insulin Secretion

@article{Doyle2003PharmacologicalAT,
  title={Pharmacological Agents That Directly Modulate Insulin Secretion},
  author={M. Doyle and J. Egan},
  journal={Pharmacological Reviews},
  year={2003},
  volume={55},
  pages={105 - 131}
}
Blood glucose levels are sensed and controlled by the release of hormones from the islets of Langerhans in the pancreas. The β-cell, the insulin-secreting cell in the islet, can detect subtle increases in circulating glucose levels and a cascade of molecular events spanning the initial depolarization of the β-cell membrane culminates in exocytosis and optimal insulin secretion. Here we review these processes in the context of pharmacological agents that have been shown to directly interact with… Expand
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