Pharmacological Agents That Directly Modulate Insulin Secretion

@article{Doyle2003PharmacologicalAT,
  title={Pharmacological Agents That Directly Modulate Insulin Secretion},
  author={M. Doyle and J. Egan},
  journal={Pharmacological Reviews},
  year={2003},
  volume={55},
  pages={105 - 131}
}
Blood glucose levels are sensed and controlled by the release of hormones from the islets of Langerhans in the pancreas. The β-cell, the insulin-secreting cell in the islet, can detect subtle increases in circulating glucose levels and a cascade of molecular events spanning the initial depolarization of the β-cell membrane culminates in exocytosis and optimal insulin secretion. Here we review these processes in the context of pharmacological agents that have been shown to directly interact with… Expand

Paper Mentions

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Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity.
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Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide.
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Long-term diazoxide treatment is not harmful to KATP channel mediated insulin secretion and may have beneficial protective effects on beta cell function, and the overall pattern of desensitization was similar to that induced by 100 microM tolbutamide. Expand
Regulation of insulin secretion and GLUT4 trafficking by the calcium sensor synaptotagmin VII.
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A key role for Syt VII is documented in peripheral glucose homeostasis through its action on both insulin secretion and GLUT4 traffic, as evidenced by constitutive expression ofGLUT4 present at the plasma membrane of fat and skeletal muscle cells and unresponsiveness to insulin. Expand
Mechanisms of action of glucagon-like peptide 1 in the pancreas.
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