Pharmacological “cross‐inhibition” of connexin hemichannels and swelling activated anion channels

@article{Ye2009PharmacologicalO,
  title={Pharmacological “cross‐inhibition” of connexin hemichannels and swelling activated anion channels},
  author={Z. Ye and N. Oberheim and H. Kettenmann and B. Ransom},
  journal={Glia},
  year={2009},
  volume={57}
}
The study of ion channels has relied heavily on the use of pharmacological blocking agents. However, many of these agents have multiple effects, which may compromise interpretation of results when the affected mechanisms/pathways mediate similar functions. Volume regulated anion channels (VRAC) and connexin hemichannels can both mediate the release of glutamate and taurine, although these channels have distinct activation stimuli and hemichannels, but not VRAC, are permeable to Lucifer Yellow… Expand
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References

SHOWING 1-10 OF 58 REFERENCES
Intracellular calcium changes trigger connexin 32 hemichannel opening
Molecular basis of calcium regulation in connexin-32 hemichannels
Inhibition of Gap Junction Hemichannels by Chloride Channel Blockers
Closure of gap junction channels by arylaminobenzoates.
Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release
P2X7 Receptors Mediate ATP Release and Amplification of Astrocytic Intercellular Ca2+ Signaling
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
Reversible inhibition of gap junctional communication by tamoxifen in cultured cardiac myocytes
...
1
2
3
4
5
...