Pharmacological, physiological and clinical implications of the discovery of cannabinoid receptors.

  title={Pharmacological, physiological and clinical implications of the discovery of cannabinoid receptors.},
  author={R. G. Pertwee},
  journal={Biochemical Society transactions},
  volume={26 2},
  • R. Pertwee
  • Published 1998
  • Chemistry, Medicine
  • Biochemical Society transactions
It is now generally accepted that many of the known pharmacological effects of cannabinoids are mediated by receptors. These are CBI, that are expressed mainly by central and peripheral neurons, and CBz, that occur mainly in immune cells [1,2]. The discovery of these receptors has prompted the development of selective CB, and CBz receptor agonists and antagonists [ 1 , 3 4 1 and has also led to the demonstration that there are endogenous agonists for these receptors in mammalian tissues [ 1,2… Expand
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The discovery of the endogenous cannabinoid system has important physiological, pathophysiological, pharmacological, and therapeutic implications, and one possible therapeutic strategy for the future is the development and use of drugs that activate cannabinoid receptors indirectly by modulating extracellular levels of endogenous cannabinoids. Expand
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  • R. Pertwee
  • Chemistry, Medicine
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  • 2000
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Findings demonstrate marked differences among cannabinoid receptor agonists in their activation of intracellular transduction pathways, providing support for the emerging concept of agonist-specific trafficking of cellular responses and further suggests strategies for developing receptors agonists with increased therapeutic utility. Expand
The Endogenous Cannabinoid, Anandamide, Activates the Hypothalamo-Pituitary-Adrenal Axis in CB1 Cannabinoid Receptor Knockout Mice
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