Pharmacologic tools to reduce bleeding in surgery.

  title={Pharmacologic tools to reduce bleeding in surgery.},
  author={Sam Schulman},
  journal={Hematology. American Society of Hematology. Education Program},
Strategies to reduce blood loss and the need for transfusions in surgery include enhancement of coagulation, inhibition of fibrinolysis, and an improved decision algorithm for transfusion based on bedside monitoring of global hemostasis. The synthetic antifibrinolytic drug tranexamic acid has emerged as an effective alternative in this respect for orthopedic and cardiac surgery. Although it seems less effective than aprotinin, it has not been associated with the increased risk of mortality of… CONTINUE READING