Pharmacologic specificity of nicotinic receptor-mediated relaxation of muscarinic receptor precontracted human gastric clasp and sling muscle fibers within the gastroesophageal junction.

@article{Braverman2011PharmacologicSO,
  title={Pharmacologic specificity of nicotinic receptor-mediated relaxation of muscarinic receptor precontracted human gastric clasp and sling muscle fibers within the gastroesophageal junction.},
  author={Alan S. Braverman and A Vegesna and Larry S. Miller and Mary F. Barbe and Mansoor I Tiwana and Kashif Hussain and Michael R Ruggieri},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={338 1},
  pages={37-46}
}
Relaxation of gastric clasp and sling muscle fibers is involved the transient lower esophageal sphincter relaxations underlying the pathophysiology of gastroesophageal reflux disease (GERD). These fibers do not contribute tone to the high-pressure zone in GERD patients, indicating their role in pathophysiology. This study identifies some mediators of the nicotine-induced relaxation of muscarinic receptor precontracted gastric clasp and sling fibers. Muscle strips from organ donors precontracted… CONTINUE READING
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Gastric clasp and lower esophageal circular muscle fibers from GERD patients with Barrett ’ s esophagitis have a decreased contractile response to cholinergic stimulation

  • L Miller, A Vegesna, AS Braverman, M Tiwana, E Miller, MR Ruggieri
  • Gastroenterology
  • 2010
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Gastric clasp and lower esophageal circular muscle fibers from GERD patients with Barrett’s esophagitis have a decreased contractile response to cholinergic stimulation. Gastroenterology 138:S–557

  • L Miller, A Vegesna, AS Braverman, M Tiwana, E Miller, MR Ruggieri
  • 2010
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