Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis.

@article{So2008PharmacologicRS,
  title={Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis.},
  author={Po-Lin So and Michele A Fujimoto and Ervin H. Epstein},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 5},
  pages={1275-84}
}
Basal cell carcinoma (BCC) is the most common human cancer. Patients with basal cell nevus syndrome (Gorlin syndrome) are highly susceptible to developing many BCCs as a result of a constitutive inactivating mutation in one allele of PATCHED 1, which encodes a tumor suppressor that is a major inhibitor of Hedgehog signaling. Dysregulated Hedgehog signaling… CONTINUE READING