Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.

@article{UlloaAguirre2004PharmacologicRO,
  title={Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.},
  author={Alfredo Ulloa-Aguirre and Jo Ann Janovick and Shaun P. Brothers and P. Michael Conn},
  journal={Traffic},
  year={2004},
  volume={5 11},
  pages={821-37}
}
The process of quality control in the endoplasmic reticulum involves a variety of mechanisms which ensure that only correctly folded proteins enter the secretory pathway. Among these are conformation-screening mechanisms performed by molecular chaperones that assist in protein folding and prevent non-native (or misfolded) proteins from interacting with other misfolded proteins. Chaperones play a central role in the triage of newly formed proteins prior to their entry into the secretion… CONTINUE READING

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