Pharmacologic rationale for regional drug delivery.

  • Jonny M. Collins
  • Published 1984 in
    Journal of clinical oncology : official journal…


Regional drug delivery is an approach designed to improve the selectivity of chemotherapy. When compared with systemic drug administration, regional delivery can potentially increase drug concentrations at tumor sites and/or lower systemic drug exposure. Pharmacokinetic analysis can evaluate or even predict the relative advantage of regional drug delivery… (More)


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