Pharmacologic profile of UR-7247, an orally active angiotensin II AT1 receptor antagonist, in healthy volunteers. p6.

  title={Pharmacologic profile of UR-7247, an orally active angiotensin II AT1 receptor antagonist, in healthy volunteers. p6.},
  author={Marc Maillard and Julien Rossat and J{\"u}rg Nussberger and Joaqu{\'i}m Ramis and Carolina Nobre Ribeiro Pontes and Michel Burnier and Hans Rudolf Brunner},
  journal={Journal of cardiovascular pharmacology},
  volume={35 3},
This study was conducted to assess the pharmacologic properties of the new orally active angiotensin II subtype I (AT1) antagonist UR-7247, a product with a half-life >100 h in humans. The experiment was designed as an open-label, single-dose administration study with four parallel groups of four healthy men receiving increasing single oral doses (2.5, 5, and 10 mg) of UR-7247 or losartan, 100 mg. Angiotensin II receptor blockade was investigated < or =96 h after drug intake, with three… Expand
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