Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells.

@article{Huang2009PharmacologicPA,
  title={Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells.},
  author={Baoying Huang and Dayanand D. Deo and Mingxuan Xia and Lyubomir T. Vassilev},
  journal={Molecular cancer research : MCR},
  year={2009},
  volume={7 9},
  pages={1497-509}
}
Cellular senescence is a stress-induced state of irreversible growth arrest thought to act as a barrier to cancer development. The p53 tumor suppressor is a critical mediator of senescence and recent in vivo studies have suggested that p53-induced senescence may contribute to tumor clearance by the immune system. Recently developed MDM2 antagonists, the nutlins, are effective p53 activators and potent antitumor agents in cells with functional apoptotic pathways. However, they only block cell… CONTINUE READING

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