Pharmacologic modulation of the whealing response to histamine in human skin: identification of doxepin as a potent in vivo inhibitor.

@article{Sullivan1982PharmacologicMO,
  title={Pharmacologic modulation of the whealing response to histamine in human skin: identification of doxepin as a potent in vivo inhibitor.},
  author={Timothy J Sullivan},
  journal={The Journal of allergy and clinical immunology},
  year={1982},
  volume={69 3},
  pages={
          260-7
        }
}
  • T. Sullivan
  • Published 1 March 1982
  • Chemistry, Medicine
  • The Journal of allergy and clinical immunology
Tricyclic antidepressants are known to exert potent in vitro H 1 antihistaminic effects. Doxepin, a heterocyclic variant of amitriptyline, is a particularly effective H 1 -antihistamine in vitro. In this study we examined the ability of doxepin to inhibit histamine-induced whealing reactions in human skin. Percutaneous introduction of histamine into skin on the volar surface of the forearm provoked a whealing response that was linearly related to the concentration of histamine from 0.0002M to 1… Expand
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