Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action.

@article{Dent2001PharmacologicIO,
  title={Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action.},
  author={Paul Washington Dent and Steven Grant},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 4},
  pages={
          775-83
        }
}
Over the last 10 years, there has been a dramatic increase in interest in the role of signaling pathways in governing neoplastic cell behavior. Much of this interest has focused on members of the MAPK[3][1] pathways, which include the ERK, the JNK, also called the SAPK, and the p38 kinase modules [( 

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