Pharmacologic increase in HIF1α enhances hematopoietic stem and progenitor homing and engraftment.

@article{Speth2014PharmacologicII,
  title={Pharmacologic increase in HIF1α enhances hematopoietic stem and progenitor homing and engraftment.},
  author={Jennifer M Speth and Jonathan Hoggatt and Pratibha Singh and Louis M. Pelus},
  journal={Blood},
  year={2014},
  volume={123 2},
  pages={203-7}
}
Hematopoietic stem cell (HSC) transplantation is a lifesaving therapy for a number of immunologic disorders. For effective transplant, HSCs must traffic from the peripheral blood to supportive bone marrow niches. We previously showed that HSC trafficking can be enhanced by ex vivo treatment of hematopoietic grafts with 16-16 dimethyl prostaglandin E2 (dmPGE2). While exploring regulatory molecules involved in dmPGE2 enhancement, we found that transiently increasing the transcription factor… CONTINUE READING
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