Pharmacologic identification of the lower esophageal sphincter.

  title={Pharmacologic identification of the lower esophageal sphincter.},
  author={James Christensen},
  journal={The Journal of clinical investigation},
  volume={49 4},
The distal 2/3 of the opossum esophagus contains only smooth muscle. Manometry shows that the most distal 1-2 cm is the lower esophageal sphincter. We used a variety of agonists to seek differences between circular muscle from the sphincteric segment and more rostral levels. Isometric contractions of strips from the distal 6 cm were recorded in vitro in response to acetylcholine, carbachol, methacholine, nicotine. DMPP, norepinephrine, norepinephrine with propranolol, barium, atropine, and… CONTINUE READING


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