Pharmacologic distinction of different orthostatic hypotension syndromes.


We studied the pressor responses to vasoactive agents in patients with orthostatic hypotension. Greater-than-normal slopes of the stimulus-response curves in patients with multiple system atrophy (Shy-drager syndrome) and idiopathic orthostatic hypotension (IOH) were consistent with deficient reflex modulation. Patients with IOH also had a shift to the left… (More)