Pharmacologic cholinesterase inhibition improves survival in experimental sepsis.

@article{Hofer2008PharmacologicCI,
  title={Pharmacologic cholinesterase inhibition improves survival in experimental sepsis.},
  author={Stefan Hofer and Christoph Eisenbach and Ivan Kre{\vs}imir Luki{\'c} and Lutz Schneider and Konrad Bode and Martina Brueckmann and Sven Mautner and Moritz Nicolas Wente and Jens Encke and Jens Werner and Alexander H Dalpke and Wolfgang Stremmel and Peter P Nawroth and Eike Martin and Peter Heinrich Krammer and Angelika Bierhaus and Markus Alexander Weigand},
  journal={Critical care medicine},
  year={2008},
  volume={36 2},
  pages={404-8}
}
OBJECTIVE Lethal sepsis occurs when an excessive inflammatory response evolves that cannot be controlled by physiologic anti-inflammatory mechanisms, such as the recently described cholinergic anti-inflammatory pathway. Here we studied whether the cholinergic anti-inflammatory pathway can be activated by pharmacologic cholinesterase inhibition in vivo. DESIGN Prospective, randomized laboratory investigation that used an established murine sepsis model. SETTING Research laboratory in a… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
53 Extracted Citations
32 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 53 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 32 references

Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak 2STAT 3 signaling pathway

  • WJ deJonge, EP vanderZanden, FO The
  • 2005

The FO, et al: Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway

  • WJ de Jonge, EP van der Zanden
  • Nat Immunol
  • 2005

Similar Papers

Loading similar papers…