Pharmacologic characterization of GABAA/benzodiazepine receptor in rat hippocampus during aging.

@article{Ruano1991PharmacologicCO,
  title={Pharmacologic characterization of GABAA/benzodiazepine receptor in rat hippocampus during aging.},
  author={Diego Ruano and J. Manuel Cano and Alberto Machado and Javier Vitorica},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={256 3},
  pages={902-8}
}
We have characterized the pharmacologic properties of the gamma-aminobutyric acid (GABAA)/benzodiazepine receptor complex in hippocampal membranes from 3-month- and 24-month-old Wistar rats. No major changes were found in [3H]flunitrazepam or [3H]muscimol binding parameters. Neither the dissociation constant(s) nor the Bmax for either ligand seemed to be modified during aging in hippocampus. Furthermore, the allosteric interaction between the barbiturates binding site and the GABA binding site… CONTINUE READING