Pharmacologic and pharmacokinetic profile of mibefradil, a T- and L-type calcium channel antagonist.

@article{Abernethy1997PharmacologicAP,
  title={Pharmacologic and pharmacokinetic profile of mibefradil, a T- and L-type calcium channel antagonist.},
  author={Darrell R. Abernethy},
  journal={The American journal of cardiology},
  year={1997},
  volume={80 4B},
  pages={4C-11C}
}
Mibefradil is a recently introduced calcium antagonist that, as a tetralol derivative, is chemically distinct from previous calcium antagonists. This article will review pertinent results from in vitro, animal, and clinical investigations to report the pharmacologic properties that distinguish mibefradil from all of the calcium channel antagonists in use today, all of which operate on the "L-type" calcium channel. Mibefradil's pharmacokinetic profile indicates it can be used as a once-daily… CONTINUE READING