Pharmacologic and molecular characterization of the vascular ETA receptor in the venomous snake Bothrops jararaca.

@article{Borgheresi2006PharmacologicAM,
  title={Pharmacologic and molecular characterization of the vascular ETA receptor in the venomous snake Bothrops jararaca.},
  author={Rosa A M B Borgheresi and Janine Marie Gisele Leroy and Alvaro Yogi and Rosangela Aparecida Dossantos and Maria Cristina Breno and Rita C A Tostes},
  journal={Experimental biology and medicine},
  year={2006},
  volume={231 6},
  pages={729-35}
}
Endothelins (ETs) and sarafotoxins (SRTXs) are active isopeptides that have very similar structures and functions. All isoforms interact with two specific G-protein-coupled receptors, ET(A) and ET(B). To characterize functional vascular ET receptors in the poisonous snake, Bothrops jararaca, cumulative concentration-response curves to ETs and SRTXs were performed in isolated aortic rings, in the absence and presence of selective ET receptor antagonists. Vascular expression of ET receptor… CONTINUE READING