Pharmacologic and clinical assessment of kratom.

@article{White2018PharmacologicAC,
  title={Pharmacologic and clinical assessment of kratom.},
  author={C. Michael White},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  year={2018},
  volume={75 5},
  pages={
          261-267
        }
}
  • C. White
  • Published 1 March 2018
  • Medicine, Biology
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
PURPOSE This article reviews the pharmacology, clinical utility, adverse effects, and abuse potential of kratom. SUMMARY The leaves of Mitragyna speciosa contain the biologically active alkaloids of kratom. Kratom exerts opioid and α-2 receptor agonistic effects as well as antiinflammatory and parasympathetic-impeding effects. There are no published human pharmacologic, pharmacokinetic, or drug interaction studies on kratom or mitragynine, making it virtually impossible to fully understand… 

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References

SHOWING 1-10 OF 34 REFERENCES

Pharmacology of Kratom: An Emerging Botanical Agent With Stimulant, Analgesic and Opioid-Like Effects

Analyses of the medical literature and select Internet sites indicate that individuals in the United States are increasingly using kratom for the self-management of pain and opioid withdrawal.

Abuse potential and adverse cognitive effects of mitragynine (kratom)

Findings provide evidence for an addiction potential with cognitive impairments for mitragynine, which suggest its classification as a harmful drug.

Experiences of Kratom Users: A Qualitative Analysis

Abstract Kratom (Mitragyna speciosa) is a psychoactive plant that has been used since at least 1836 in folk medicine in Southeast Asian countries. More recently, kratom has become widely available in

From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction

A Case Report of Inpatient Detoxification after Kratom (Mitragyna speciosa) Dependence

These observations support the idea that kratom dependence syndrome is due to short-acting opioid receptor agonist activity, and suggest that dihydrocodeine and lofexidine are effective in supporting detoxification.

Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users.

Notes from the Field: Kratom (Mitragyna speciosa) Exposures Reported to Poison Centers - United States, 2010-2015.

CDC characterized kratom exposures that were reported to poison centers and uploaded to the National Poison Data System (NPDS) during January 2010-December 2015.

Social Functioning of Kratom (Mitragyna speciosa) Users in Malaysia

It is suggested that chronic kratom administration does not significantly impair social functioning of users in a natural context in Malaysia, despite being dependent on kratom for prolonged periods of time.

How MDMA's Pharmacology and Pharmacokinetics Drive Desired Effects and Harms

The desirable and adverse effects of MDMA are extensions of its fascinating pharmacologic and pharmacokinetic profile and are needed for education, prevention of harm, and treatment.