Pharmacologic analysis of positive chronotropic and inotropic responses to octopamine.

@article{Chiba1976PharmacologicAO,
  title={Pharmacologic analysis of positive chronotropic and inotropic responses to octopamine.},
  author={Shigetoshi Chiba},
  journal={The Tohoku journal of experimental medicine},
  year={1976},
  volume={118 3},
  pages={247-53}
}
Effects of octopamine on sinus rate and atrial contractility were investigated using the isolated atrium preparation of the dog which perfused with heparinized arterial blood led from a support dog. When octopamine, dopamine or norepinephrine was administered into the cannulated sinus node artery, positive chronotropic and inotropic responses were dose-relatedly induced from 0.1 mug, 0.1 mug or 0.01 mug, respectively. The D.R.50 values (dose ratio at 50% maximum response) of octopamine… CONTINUE READING

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